Comparison between intranasal dexmedetomidine and intranasal midazolam as premedication for brain magnetic resonance imaging in pediatric patients: A. Intranasal dexmedetomidine has been used an effective and safe alternative premedication to oral midazolam in children. At a dose of 2micrograms/kg. Background Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable.

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Support Center Support Center. Subjects were contacted the night before the procedure and were given relevant instructions regarding when and where to arrive and fasting time. However, the non-DEX cohort had a longer preprocedure time Table 5.

An effective route of sedation preserves background activity for pediatric electroencephalograms. Premedication with midazolam in young children: The non-DEX cohort had more subjects in the deep sedation cohort, subjects Author information Copyright and License information Disclaimer.

Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

We did not compare side effects between the IN DEX cohort and each of the sedation medications individually due to inadequate sample size, but we believe that this should be intraasal in future studies. This allows for administration of a small volume which is dispensed quickly. Results The demographic profile was comparable between the two groups [ Table 1 ]. Comparison of two different intranasal doses of dexmedetomidine in children for magnetic resonance imaging sedation.


In our study, dexmedetomidune median sedation score at the time of cannulation was 4 3—6 for Group M compared with 3 3—5 for Group D [ Figure 4 ].

Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

Two pediatric critical care physicians who are experienced in providing PSA outside of the operating room provided all PSA. High dose dexmedetomidine as the sole sedative for pediatric mri.

Dexmedetomidine is only available in an intravenous formulation; intravenous preparation has been used through oral, transmucosal, and intranasal routes. However, few studies have reported on the intranasal use of dexmedetomidine in radiological procedures.

Intranasal Dexmedetomidine as a Sedative for Pediatric Procedural Sedation

Hence, a better sedation score was obtained for Group D, similar intrannasal the results reported by Sheta et al. None of the children in both groups had untoward complications, such as bradycardia, hypotension, hypertension, and respiratory depression, after premedication. Sedation of infants and children outside of the operating room.

Methods This was a prospective observational study, performed in our procedural suite, located at a tertiary medical center. The intranasal drug was dripped into both nostrils using a 1-mL syringe, with the patients in the recumbent position.

The difference in onset time was statistically significant with early onset in midazolam. Your email address will not be published.


No significant differences were observed in demographic, hemodynamic, and respiratory parameters. Conflicts of interest There are no dsxmedetomidine of interest. Sixteen of 30 children IN dexmedetomidine may be used for non-invasive pediatric procedural sedation. All of this is anecdotal and should be studied further.

This was a prospective observational study, performed in our procedural suite, located at a tertiary medical center. Comparison of level of sedation between the groups at the time of induction. Iintranasal has been extensively studied intranasally in both children and adults. The level of sedation was noted as either moderate or deep in 31 and 78 patients, respectively.

The mean age untranasal weight were 2. In this prospective, randomized, double-blind study, we dexmedetomdiine intranasal midazolam 0. The plan of care was then formulated and discussed with the family. In addition, the use of the nasal MAD mucosal atomization device has allowed quick and even administration of the drug. Repeated measurements data were analyzed using the paired t -test, and binary data were analyzed using Chi-squared test.